Principles of Nucleotide Activity
PHA 6535 Principles of Nucleotide Activity


This is a 2-credit course.


This course will introduce students to the chemical structure of DNA and RNA; the synthetic processes for DNA and RNA synthesis; biochemical reactions and pathways for nucleotide synthesis; DNA replication, transcription and translation; covalent and reversible interactions of nucleic acids with small molecules and proteins and an overview of techniques for the analysis of nucleic acids.


Module Topic
Module 1 DNA and RNA Structure
Module 2 DNA Packaging, Replication, Repair, and Recombination
Module 3 RNA Sequence Information
Module 4 Nucleotide Biosynthesis
Module 5 The Role of Nucleotides in Protein Synthesis and Protein-Nucleic Acid Interactions
Module 6 Reversible and Covalent Interactions of Nucleic Acids with Small Molecules
Module 7 Chemical Synthesis
Module 8 Techniques Applied to Nucleic Acids


Please review our recommended course order.

Required Materials

Required text:
Lehninger Principles of Biochemistry 8th Edition
by David L. Nelson, Michael M. Cox
Publisher: MacMillan Learning; 8th edition (2021)
E-book ISBN:  9781319322342 
Loose-Leaf ISBN:  9781319381479 
Paperback ISBN:  9781319228002 

Please note: this is the same text that is required for Metabolic Biochemistry, PHA 6935 

Library Access

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