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Credits
This course is 3 credits.
Description
This course provides a strong conceptual foundation of enzymology and mechanisms of drug biotransformation pathways. As a foundation for learning, we will provide examples of drugs and other xenobiotics that exhibit toxicity related to biotransformation. Students are expected to use information presented in each module to develop and complete given assignments. Other activities will include online discussions of current news articles and scientific publications that relate to drug metabolism, toxicology and biochemistry.
Prerequisites
Please review our recommended course order.
Topics
| Module | Topic |
|---|---|
| Module 1 | Overview of Xenobiotic Metabolism |
| Module 2 | Cytochrome P450 |
| Module 3 | Flavin Monooxygenase and Other Oxidative Enzymes |
| Module 4 | Ester/Amide Hydrolysis |
| Module 5 | Epoxide Hydrolases |
| Module 6 | Glucuronosyltransferases and Glucosyltransferase |
| Module 7 | Sulfotransferases |
| Module 8 | Glutathione S-transferases |
| Module 9 | Other Phase II Reactions |
| Module 10 | Transport of Xenobiotics and Their Metabolites |
| Module 11 | Metabolism and Toxicity General Concepts |
| Module 12 | Metabolic Activation of Drugs |
| Module 13 | Metabolic Activation of Industrial Chemicals |
| Module 14 | Metabolic Activation of Pyrolysis Products |
| Module 15 | Metabolic Activation of Natural Products |
Library Access
UF online graduate students enjoy the same library privileges as on-campus students. Visit the University of Florida Libraries to find books, journals, and more.