Organic Structure Elucidation
PHA 6935 Organic Structure Elucidation


This is a 3-credit course.


This course introduces the use of spectroscopic methods and tools (IR, NMR, MS, UV) for the accurate determination of molecular structure. This skill is essential for chemists in many areas, such as medicinal chemistry, process chemistry, natural products chemistry, forensic chemistry, and many other sub-specialties of analytical chemistry. This course will prepare students with an up-to-date presentation of the tools used for the advanced analysis and structure elucidation of organic molecules. Additionally, this course will address the structural aspects of the organic solid-state, and the tools that are used for the characterization of solid organic materials. The student will not emerge from this course as an expert in structure elucidation, but should have the basic tools to begin to understand what level of detail is necessary in their structure elucidation projects, the skills to begin to answer those questions independently, and an idea of the resources available to them if they encounter difficulty.


Please review our recommended course order.


Module Topic
Module 1 Introduction to structure elucidation
Module 2 Separation techniques and isolation of compounds
Module 3 Ultraviolet and Infrared Spectrophotometry
Module 4 Introduction to Mass spectrometry
Module 5 Advanced topics and tools in Mass spectrometry
Module 6 Introduction to Nuclear Magnetic Resonance spectroscopy
Module 7 Two-dimensional homo- and heteronuclear NMR
Module 8 Advanced topics and tools in NMR spectroscopy
Module 9 Organic solid state analysis techniques
Module 10 Practical applications of structure elucidation techniques

If you wish to enroll for this course and are currently not a student in another program, please follow the application instructions for non-degree applications. If you have additional questions about the content of this course, please contact Professor Oliver Grundmann (

Required Materials

Starting in Spring 2024, students have to pay a fee to access the virtual lab simulations offered by Labster. That fee is currently $75 and students will be asked to pay at the start of the semester with a credit card.

Library Access

Distance Education and UF Online Students enjoy the same library privileges as on-campus students.
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